Nowadays, high-dose chemotherapy and radiotherapy treatments for cancer are more effective but can severely affect the ovarian follicular store, compromising the fertility of surviving young patients. A promising alternative to prevent fertility loss in these patients is the cryopreservation and transplantation of ovarian tissue. Slices of animal and human ovarian tissue have been shown to survive the cryopreservation process. After transplantation, follicular development and restoration of hormone secretion have been observed in animal and human studies. This review addresses recent developments on ovarian tissue transplantation in animals and humans. We also illustrate the indications and technical difficulties of the procedure and the ethical issues that should be considered.

中文翻译：

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卵巢组织移植在实验生物学和医学中的应用。

如今，针对癌症的大剂量化学疗法和放射疗法更有效，但会严重影响卵巢的卵泡储备，损害了尚存的年轻患者的生育能力。防止这些患者生育力丧失的一种有希望的替代方法是冷冻保存和移植卵巢组织。动物和人类卵巢组织的切片已显示出可以在冷冻保存过程中存活下来。移植后，在动物和人体研究中已观察到卵泡发育和激素分泌的恢复。这篇综述阐述了动物和人类卵巢组织移植的最新发展。我们还将说明该程序的适应症和技术难度以及应考虑的道德问题。