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DNA vaccines against human immunodeficiency virus type 1 in the past decade.
Clinical Microbiology Reviews ( IF 36.8 ) Pub Date : 2004-04-16 , DOI: 10.1128/cmr.17.2.370-389.2004
Malavika Giri 1 , Kenneth E Ugen , David B Weiner
Affiliation  

This article reviews advances in the field of human immunodeficiency virus type 1 (HIV-1) and AIDS vaccine development over the last decade, with an emphasis on the DNA vaccination approach. Despite the discovery of HIV-1 and AIDS in humans nearly 20 years ago, there is no vaccine yet that can prevent HIV-1 infection. The focus has shifted toward developing vaccines that can control virus replication and disease progression by eliciting broadly cross-reactive T-cell responses. Among several approaches evaluated, the DNA-based modality has shown considerable promise in terms of its ability to elicit cellular immune responses in primate studies. Of great importance are efforts aimed at improvement of the potency of this modality in the clinic. The review discusses principles of DNA vaccine design and the various mechanisms of plasmid-encoded antigen presentation. The review also outlines current DNA-based vaccine strategies and vectors that have successfully been shown to control virus replication and slow disease progression in animal models. Finally, it lists recent strategies that have been developed as well as novel approaches under consideration to enhance the immunogenicity of plasmid-encoded HIV-1 antigen in various animal models.

中文翻译:

在过去十年中,针对人类1型免疫缺陷病毒的DNA疫苗。

本文回顾了近十年来人类1型免疫缺陷病毒(HIV-1)和AIDS疫苗领域的发展,重点是DNA疫苗接种方法。尽管将近20年前在人类中发现了HIV-1和AIDS,但尚无可预防HIV-1感染的疫苗。重点已转向开发可通过引起广泛的交叉反应性T细胞反应来控制病毒复制和疾病进展的疫苗。在评估的几种方法中,基于DNA的方法在灵长类动物研究中引发细胞免疫应答的能力方面显示出了可观的前景。旨在改善这种形式在临床上的效力的努力是非常重要的。该综述讨论了DNA疫苗设计的原理以及质粒编码抗原呈递的各种机制。该综述还概述了当前基于DNA的疫苗策略和载体,这些策略和载体已成功地显示出可在动物模型中控制病毒复制并减慢疾病进程。最后,它列出了已开发的最新策略以及正在考虑增强各种动物模型中质粒编码的HIV-1抗原的免疫原性的新方法。
更新日期:2019-11-01
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