Patients with defects in phagocytic function are predisposed to intracellular microorganisms and typically have early dissemination of the infection. Recognition of the underlying disorder and aggressive antimicrobial therapy has been beneficial for the patients. Improved understanding of the pathophysiology has also affected patient management by allowing specific, targeted immunomodulatory intervention. The disorders described in this review are not common but have had a significant impact on our understanding of the role of phagocytic cells in host defense. Conversely, understanding the role of the neutrophil and macrophage in infection has benefited not just the patients described in this review but also other patients with similar disease processes.

中文翻译：

---

具有吞噬功能遗传缺陷的患者的感染。

具有吞噬功能缺陷的患者易患细胞内微生物，并且通常较早传播感染。对潜在疾病的认识和积极的抗菌治疗对患者是有益的。通过允许进行特定的，有针对性的免疫调节干预，对病理生理学的更好理解也影响了患者的治疗。这篇综述中描述的疾病并不常见，但对吞噬细胞在宿主防御中的作用的理解产生了重大影响。相反，了解中性粒细胞和巨噬细胞在感染中的作用不仅有益于本综述中描述的患者，而且有益于其他具有相似疾病过程的患者。