当前位置: X-MOL 学术Hum. Ecol. Risk Assess. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Applications of the Poly-K Statistical Test to Life-Time Cancer Bioassay Studies.
Human and Ecological Risk Assessment ( IF 4.3 ) Pub Date : 2010-02-12 , DOI: 10.1080/10807030903153360
Mulugeta Gebregziabher 1 , David Hoel
Affiliation  

The statistical analysis of cancer bioassay data has historically depended on the pathological determination of the experimental animal's cause of death. The poly-k statistical test has provided a method of statistical analysis of animal bioassay data without the need for cause of death information. The test has been shown to have good statistical properties in the typical 2-year cancer bioassay. However, while the poly-k test has been applied to chronic lifetime animal studies, it has not been formally evaluated with respect to the operating characteristics of this statistical test when applied to such studies. Thus, our objective is to assess the performance of the poly-k test for lifetime studies and to make comparisons with other tests. We observed in one recent lifetime study of the gasoline additive methyl tertiary butyl ether (MTBE) that the application of the poly-k test was not statistically robust. Simulation studies were subsequently conducted for a limited number of scenarios of lifetime cancer bioassays. These simulations showed that the poly-k test is not statistically robust for testing effect of increasing dose in some lifetime cancer studies.



中文翻译:

Poly-K 统计检验在终生癌症生物测定研究中的应用。

癌症生物测定数据的统计分析历来依赖于对实验动物死因的病理学确定。poly-k 统计检验提供了一种无需死因信息即可对动物生物测定数据进行统计分析的方法。在典型的 2 年癌症生物测定中,该测试已被证明具有良好的统计特性。然而,虽然 poly-k 测试已应用于慢性终生动物研究,但在应用于此类研究时,尚未正式评估此统计测试的操作特性。因此,我们的目标是评估用于寿命研究的 poly-k 测试的性能,并与其他测试进行比较。我们在最近的一项汽油添加剂甲基叔丁基醚 (MTBE) 寿命研究中观察到,poly-k 测试的应用在统计上并不稳健。随后对有限数量的终生癌症生物测定方案进行了模拟研究。这些模拟表明,在某些终生癌症研究中,poly-k 检验对于测试增加剂量的影响在统计上并不稳健。

更新日期:2010-02-12
down
wechat
bug