We have isolated a human cDNA encoding a protein of 1288 amino acids that shows 77% identity in amino acid sequence to XCAP-C, Xenopus chromosome-associated polypeptide-C, belonging to the family of structural maintenance of chromosomes (SMC), which is known to play a crucial role in the proper condensation and segregation of mitotic chromosomes. In particular, an almost 200-amino-acid domain in the N-terminal, including an NTP-binding motif and that in the C-terminal domain, including a DA-box, were well conserved and showed 95% identity between human and frog, indicating that these two domains are functionally very important. The transcript of this gene was expressed ubiquitously in various human tissues, but thymus, testis, and colon seemed to express this gene more abundantly. We also determined its chromosomal location at 3q26.1 by fluorescence in situ hybridization.

中文翻译：

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与非洲爪蟾XCAP-C基因同源的人类cDNA的分离和鉴定，该基因属于染色体的结构维护（SMC）家族。

我们已经分离出一种人类cDNA，编码一种1288个氨基酸的蛋白质，该蛋白质在氨基酸序列上与XCAP-C（非洲爪蟾染色体相关的多肽-C）具有77％的同一性，属于染色体结构维持家族（SMC），已知在有丝分裂染色体的正确凝结和分离中起关键作用。尤其是，在N端（包括NTP结合基序）和在C端域（包括DA-box）中的近200个氨基酸结构域都非常保守，并显示出人与青蛙之间95％的同一性，表明这两个域在功能上非常重要。该基因的转录本在各种人体组织中普遍表达，但是胸腺，睾丸和结肠似乎更大量地表达该基因。我们还确定了其在3q26的染色体位置。