Islet cell transplantation is a promising functional cure for type 1 diabetes; however, maintaining long-term islet graft function and insulin independence is difficult to achieve. In this short report we present a patient with situs inversus, who at the time of islet transplantation had a 26-year history of type 1 diabetes, complicated by hypoglycemic unawareness and severe hypoglycemic events. After a single allogeneic islet transplant of a low islet mass, and despite developing de novo anti-insulin and anti-GAD65 autoantibodies, the patient has remarkably maintained insulin independence with tight glycemic control and normal metabolic profiles for 10 years, after receiving prolonged non-T-cell depleting immunosuppression.

胰岛细胞移植是治疗1型糖尿病的有希望的功能性疗法。但是，维持胰岛移植物的长期功能和胰岛素独立性是很难实现的。在这份简短的报告中，我们介绍了一位患有逆位的患者，该患者在胰岛移植时具有26年的1型糖尿病病史，并伴有低血糖意识和严重的低血糖事件。在进行了一次低胰岛质量的异基因胰岛移植后，尽管开发了从头抗胰岛素和抗GAD65自身抗体，但在长期接受非胰岛素治疗后，该患者在维持严格的血糖控制和正常代谢状况的情况下，仍显着保持了胰岛素独立性。 T细胞消耗性免疫抑制。