The syntheses and cytotoxic activity of coumarin-estrogen conjugates are described. In vitro results indicated that conjugates 10, 11 and 13 show growth inhibitory activities at 5-dose concentration (100, 10, 1, 0.1, 0.01 muM) against the following NCI-7- human breast cancer cell lines: BT-549, HS 578T, MCF 7, MDA-MB-231/ATCC, MDA-MB-435, NCI/ADR-RES, and thus serve as new leads for further development of antibreast cancer agent.

中文翻译：

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香豆素-雌激素偶联物对乳腺癌细胞系的合成和抗增殖活性

描述了香豆素-雌激素缀合物的合成和细胞毒活性。体外结果表明，偶联物 10、11 和 13 在 5 剂量浓度（100、10、1、0.1、0.01 μM）下对以下 NCI-7-人乳腺癌细胞系显示出生长抑制活性：BT-549、HS 578T、MCF 7、MDA-MB-231/ATCC、MDA-MB-435、NCI/ADR-RES，从而成为进一步开发抗乳腺癌药物的新线索。