A series of N,N'-Bis(2-hydroxylbenzyl)-1,2-ethanediamine derivatives and its schiff bases were synthesized, characterized and screened for in vitro antimicrobial activity against Staphylococcus aureus, Pseudomonas aeruginosa and Salmonella enterica. Result indicated that the ethylenediamine derivatives, N,N'-Bis(2-hydroxy-5-bromobenzyl)-1,2-ethanediamine (21), and N,N'-Bis(2-hydroxy-5-chlorobenzyl)-1,2-ethanediamine (22) showed the most favorable antimicrobial activity exhibiting LC(50) of 11.6 and 8.79 muM against S.enterica, 86 and 138 muM against P. aeruginosa, and 140 and 287 muM against S. aureus, respectively. These compounds displayed highest level of resistance with S. aureus. Thus, the high level of activity seen with the compounds (21, 22) suggests that these compounds could serve as the leads for development of novel synthetic compounds with enhanced antimicrobial activity.

中文翻译：

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N,N-双(2-羟基苄基)-1,2-乙二胺衍生物的合成及抗菌活性

合成、表征和筛选了一系列 N，N'-双 (2-羟基苄基)-1，2-乙二胺衍生物及其席夫碱，并筛选了对金黄色葡萄球菌、铜绿假单胞菌和肠道沙门氏菌的体外抗菌活性。结果表明乙二胺衍生物N,N'-双(2-羟基-5-溴苄基)-1,2-乙二胺(21)和N,N'-双(2-羟基-5-氯苄基)-1 ,2-乙二胺 (22) 显示出最有利的抗微生物活性，LC(50) 对 S.enterica 的 LC(50) 分别为 11.6 和 8.79 muM，对铜绿假单胞菌分别为 86 和 138 muM，对金黄色葡萄球菌分别为 140 和 287 muM。这些化合物对金黄色葡萄球菌表现出最高水平的抗性。因此，化合物 (21,