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High-fat diet withdrawal modifies alcohol preference and transcription of dopaminergic and GABAergic receptors.
Journal of Neurogenetics ( IF 1.9 ) Pub Date : 2018-12-05 , DOI: 10.1080/01677063.2018.1526934
Luana Martins de Carvalho 1 , Juliana Lauar Gonçalves 1, 2 , Agatha Sondertoft Braga Pedersen 1 , Samara Damasceno 1 , Renato Elias Moreira Júnior 1 , Tatiani Uceli Maioli 3 , Ana Maria Caetano de Faria 4 , Ana Lúcia Brunialti Godard 1
Affiliation  

The bidirectional and positive relation between the ingestion of fat and alcohol has become the subject of extensive discussion. However, this relation is more studied in animal models of binge eating with intermittent access of high-fat diet or in a model of short period of this diet consumption. Here, we developed a model to elucidate how chronic high-fat diet and its withdrawal influence alcohol intake (two-bottle choice) and anxiety behavior (marble burying test). In the first experimental stage, animals were fed on standard (AIN93G) or high sugar and butter (HSB) diet for 8 weeks. Then, a protocol of free-choice between water and a 10% alcohol solution was introduced, and the HSB diet was replaced with AIN93G in two experimental groups. The result obtained with this model point out that the relation among high-fat diet consumption and alcohol intake appears to depend on the presence or absence of the diet when alcohol intake is evaluated, and that an imbalance in the mesocorticolimbic dopaminergic pathway, observed by the transcriptional regulation of the dopamine receptors (Drd1/Drd2) and GABAB receptors subunit (Gabbr1/Gabbr2), can be driving the alcohol intake.



中文翻译:

高脂饮食戒断会改变酒精的偏好以及多巴胺能和GABA能受体的转录。

摄入脂肪和酒精之间的双向积极关系已成为广泛讨论的主题。但是,这种关系在间歇性进食高脂饮食的暴饮暴食动物模型中或在这种饮食消耗的短期模型中得到了更多研究。在这里,我们开发了一个模型来阐明慢性高脂饮食及其戒断如何影响酒精摄入(两瓶选择)和焦虑行为(大理石掩埋测试)。在第一个实验阶段,以标准(AIN93G)或高糖和黄油(HSB)饮食喂养动物8周。然后,引入了水和10%酒精溶液之间自由选择的方案,并且在两个实验组中用AIN93G代替了HSB饮食。Drd1 / Drd2)和GABA B受体亚基(Gabbr1 / Gabbr2),可以驱动酒精摄入。

更新日期:2018-12-05
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