Linezolid is a synthetic antimicrobial agent belonging to the oxazolidinone class. Since its approval in the year 2000 until now, linezolid remains the main representative drug for the oxazolidinone class of drugs, which is used in therapy due to its unique mode of action, which involves inhibition of protein synthesis. As linezolid holds great importance in antimicrobial therapy, it is necessary to compile the various analytical methods that have been reported in the literature for its analysis. Analytical techniques used for pharmaceutical analyses and therapeutic drug monitoring play an important role in comprehending the aspects regarding bioavailability, bioequivalence, and therapeutic monitoring during patient follow-ups. Even though linezolid has had the approval for clinical use for more than 18 years now, most of the analytical methods for its determination reported in the scientific literature are the ones which utilize HPLC. Therefore, the present review provides a summary of the HPLC-based methods used in the determination and quantification of linezolid in different matrices since the time of its discovery.

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基于HPLC的利奈唑胺定量分析方法的重要综述。

利奈唑胺是恶唑烷酮类的合成抗菌剂。自从2000年获得批准以来，利奈唑胺仍然是恶唑烷酮类药物的主要代表药物，由于其独特的作用方式（涉及抑制蛋白质合成）而被用于治疗。由于利奈唑胺在抗菌治疗中非常重要，因此有必要汇编文献中报道的各种分析方法进行分析。用于药物分析和治疗药物监测的分析技术在理解患者随访期间有关生物利用度，生物等效性和治疗监测的方面起着重要作用。即使利奈唑胺已获临床使用许可超过18年，科学文献中报道的大多数测定方法都是利用HPLC的方法。因此，本综述提供了自发现以来基于HPLC的方法在不同基质中利奈唑胺测定和定量中的概述。