Plants, fungi, and some protists possess a more branched electron transport chain in their mitochondria compared to canonical one. In these organisms, the electron transport chain contains several rotenone-insensitive NAD(P)H dehydrogenases. Some are located on the outer surface, and others are located on the inner surface of the inner mitochondrial membrane. The putative role of these enzymes still remains elusive, but they may prevent the overreduction of the electron transport chain components and decrease the production of reaction oxygen species as a consequence. The last two decades resulted in the discovery of alternative rotenone-insensitive NAD(P)H dehydrogenases present in representatives of fungi and protozoa. The aim of this review is to gather and focus on current information concerning molecular and functional properties, regulation, and the physiological role of fungal and protozoan alternative NAD(P)H dehydrogenases.

与经典植物相比，植物，真菌和一些原生生物的线粒体中具有更分支的电子传输链。在这些生物中，电子传输链包含几种鱼藤酮不敏感的NAD（P）H脱氢酶。一些位于线粒体内膜的外表面，而其他位于线粒体内膜的内表面。这些酶的假定作用仍然难以捉摸，但是它们可以防止电子传输链组分的过度还原并因此减少反应氧物种的产生。在过去的二十年中，发现了在真菌和原生动物代表中存在的对鱼藤酮不敏感的NAD（P）H脱氢酶。这篇评论的目的是收集和关注有关分子和功能特性，调控，