This study explored the potential association between chronic exposure to pesticide mixtures including paraquat and respiratory outcomes among Colombian farmers. Sociodemographic and occupational data, respiratory symptoms and spirometric data were collected. Paraquat in spot urine samples were quantified with solid-phase extraction high-performance liquid chromatography. Multiple Poisson regressions with robust variance were used to determine factors associated with respiratory outcomes. Profiles of pesticide mixtures used were identified among 217 farmworkers, but profenofos and methamidophos-based mixtures were more frequent. Chronic paraquat exposure was slightly associated with self-reported asthma (PR: 1.06; 95% CI 1.00 to 1.13). Different pesticide mixtures were associated with flu, thoracic pain, allergic rhinitis, and obstructive pattern in spirometry. Although acute exposure to paraquat is low among Colombian farmers participating in the study, associations between respiratory outcomes and chronic pesticide mixtures exposure including profenofos, methamidophos or glyphosate require further specific studies.

中文翻译：

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哥伦比亚农民中慢性农药混合物的暴露，包括百草枯和呼吸的结果。

这项研究探讨了哥伦比亚农民中长期接触农药混合物（包括百草枯）与呼吸结果之间的潜在联系。收集了社会人口统计学和职业数据，呼吸道症状和肺活量数据。用固相萃取高效液相色谱法定量测定尿样中的百草枯。采用具有强方差的多重Poisson回归来确定与呼吸结局相关的因素。在217名农场工人中确定了所使用的农药混合物的概况，但是基于Profenofos和甲胺磷的混合物更为频繁。慢性百草枯暴露与自我报告的哮喘略有相关（PR：1.06； 95％CI 1.00至1.13）。不同的农药混合物与流感，胸痛，过敏性鼻炎，肺活量测定中的阻塞模式。尽管参与该研究的哥伦比亚农民对百草枯的急性暴露率较低，但是呼吸结果与慢性农药混合物（包括丙氧磷，甲胺磷或草甘膦）的暴露之间的关联仍需要进一步的具体研究。