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Curcumin pyrazole blocks lipopolysaccharide-induced inflammation via suppression of JNK activation in RAW 264.7 macrophages.
Asian Pacific Journal of Allergy and Immunology ( IF 5 ) Pub Date : 2017-12-17 , DOI: 10.12932/ap-130417-0073
Nathnarin Somchit 1 , Rungruedee Kimseng 1 , Rana Dhar 1 , Poonsit Hiransai 1 , Chatchawan Changtam 2 , Apichart Suksamrarn 3 , Wilanee Chunglok 4 , Warangkana Chunglok 1
Affiliation  

Targeting inflammatory macrophages and their products is an effective method for controlling inflammation. The pyrazole analog of curcumin (curcumin pyrazole, PYR) has been reported to possess superior anti-inflammatory activity to curcumin (CUR). However, the role of PYR anti-inflammatory activity in macrophages has not yet been elucidated.

中文翻译:

姜黄素吡唑通过抑制RAW 264.7巨噬细胞中的JNK活化来阻断脂多糖诱导的炎症。

靶向炎性巨噬细胞及其产物是控制炎症的有效方法。姜黄素的吡唑类似物(姜黄素吡唑,PYR)据报道具有优于姜黄素(CUR)的抗炎活性。然而,尚未阐明PYR抗炎活性在巨噬细胞中的作用。
更新日期:2020-08-21
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