Catecholamine neurotransmission plays a key role in regulating a variety of behavioral and physiologic processes, and its dysregulation is implicated in both neurodegenerative and neuropsychiatric disorders. Over the last four decades, in vivo electrochemistry has enabled the discovery of contrasting catecholamine regulation in the brain. These rapid and spatially resolved measurements have been conducted in brain slices, and in anesthetized and freely behaving animals. In this review, we describe the methods enabling in vivo measurements of dopamine and norepinephrine, and subsequent findings regarding their release and regulation in intact animals. We thereafter discuss key studies in awake animals, demonstrating that these catecholamines are not only differentially regulated, but are released in opposition of each other during appetitive and aversive stimuli.

中文翻译：

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行为大脑中邻苯二酚神经传递的相反调节：从电化学角度的药理学见解。

儿茶酚胺神经传递在调节各种行为和生理过程中起关键作用，其失调与神经退行性疾病和神经精神疾病有关。在过去的四十年中，体内电化学技术已经发现了大脑中儿茶酚胺调节的对比。这些快速和空间分辨的测量已在脑片，麻醉和自由行为的动物中进行。在这篇综述中，我们描述了能够在体内测量多巴胺和去甲肾上腺素的方法，以及有关它们在完整动物中释放和调节的后续发现。此后，我们讨论了在清醒动物中的关键研究，证明了这些儿茶酚胺不仅受到不同的调节，