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Linezolid-A Review of Analytical Methods in Pharmaceuticals and Biological Matrices.
Critical Reviews in Analytical Chemistry ( IF 5 ) Pub Date : 2019-04-08 , DOI: 10.1080/10408347.2019.1599709
K S Kokilambigai 1 , K S Lakshmi 1 , A Sai Susmitha 1 , R Seetharaman 1 , J Kavitha 1
Affiliation  

Bacterial resistance to antibiotics is a growing phenomenon in the world. Considering the relevance of antimicrobials for population and the reduction in the registration of new antimicrobials by regulatory agencies, proper quality control is required to minimize the spread of bacterial resistance and ensure the effectiveness of a treatment, as well as safety for the patient. The recent addition to the antimicrobial world is the oxazolidinone classes of antibiotics, especially useful to treat infections caused by Gram-positive bacteria. Eperezolid and linezolid (LIN) are the two members of the oxazolidinone class of antibiotics. LIN was the first oxazolidinone approved by the Food and Drug Administration. The present review focuses on the analytical methods for the assessment of LIN in pharmaceuticals and biological matrices. The critical validation parameters like the linearity, limit of detection, limit of quantification are discussed for the individual method. Also the critical quality attributes like the sensitivity and the sample preparation techniques for bioanalytical methods are also discussed. Furthermore, some future trends that can be incorporated in the determination of similar drugs are also suggested.

中文翻译:

利奈唑胺-药品和生物基质中分析方法的综述。

细菌对抗生素的耐药性在世界范围内正在日益增加。考虑到抗菌药物与人群的相关性以及监管机构对新抗菌药物注册的减少,需要进行适当的质量控制,以最大程度地减少细菌耐药性的传播并确保治疗的有效性以及对患者的安全性。抗菌领域最近增加了恶唑烷酮类抗生素,特别适用于治疗由革兰氏阳性细菌引起的感染。Eperezolid和Linezolid(LIN)是恶唑烷酮类抗生素的两个成员。LIN是食品和药物管理局批准的首个恶唑烷酮。本综述着重于评估药物和生物基质中LIN的分析方法。讨论了每种方法的关键验证参数,如线性,检测限,定量限。还讨论了关键的质量属性,例如灵敏度和生物分析方法的样品制备技术。此外,还提出了一些未来趋势,可以将其纳入类似药物的测定中。
更新日期:2020-02-14
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