Background

To study hippocampus subfield volumes in patients after microsurgical clipping (MC) and/or endovascular coiling (EC) of intracranial aneurysms.

Methods

Hippocampus subfield volumetry was performed using FreeSurfer v6.0 in 51 patients (35 females, mean age 54.9 ± 11.9 years, range 24–78 years). Visual inspection of image and segmentation quality was performed prior to statistical analyses. Multiple regression analysis, controlled for age, sex, and side of treatment, was used to assess the impact of prior MC and history of subarachnoid haemorrhage (SAH) on hippocampus subfield volumes (cornu ammonis (CA)-2/3, CA-4, subiculum). Partial correlation analyses were used to assess effect of multiple treatments on hippocampus subfield volumes.

Results

Prior MC was significantly associated with lower hippocampal subfield volumes in MC patients for right and left CA-2/3 (β = -22.32 [-40.18, -4.45]; p = 0.016 and β = -20.03 [-39.38, -0.68]; p = 0.043) and right CA-4 (β = -17.00 [-33.86, 0.12]; p = 0.048). History of SAH was not significantly associated with hippocampal subfield volumes. We observed a higher disease burden in the MC cohort. The number of aneurysms correlated with right-sided hippocampal subfield volumes while the number of treatment interventions did not.

Conclusion

In this explorative study, we found that history of MC was significantly associated with lower volumes in distinct hippocampal subfields, which may be a consequence of a more extensive treatment. This could indicate specific atrophy of CA-2/3 after MC and should motivate hippocampal subfield assessment in larger cohorts.

中文翻译：

---

显微外科手术或血管内治疗颅内动脉瘤后的海马子区容积测定研究。

背景

研究颅内动脉瘤的显微外科手术修剪（MC）和/或血管内卷曲（EC）后患者海马区的体积。

方法

使用FreeSurfer v6.0对51例患者（35名女性，平均年龄54.9±11.9岁，范围24-78岁）进行了海马亚野量测定。在进行统计分析之前，对图像和分割质量进行视觉检查。采用年龄，性别和治疗方式进行的多元回归分析来评估先前的MC和蛛网膜下腔出血（SAH）历史对海马子场体积的影响（角膜氨化（CA）-2/3，CA-4 ，subiculum）。使用偏相关分析来评估多种治疗对海马区子体积的影响。

结果

左右CA-2 / 3的MC患者中，先前的MC与较低的 海马亚视野量显着相关（β = -22.32 [-40.18，-4.45]；p  = 0.016和β  = -20.03 [-39.38，-0.68] ；p  = 0.043）和右CA-4（β  = -17.00 [-33.86，0.12]；p  = 0.048）。SAH的病史与海马亚视野量没有显着相关。我们在MC队列中观察到较高的疾病负担。动脉瘤的数量与右侧海马区的体积相关，而治疗干预的数量则没有。

结论

在这项探索性研究中，我们发现MC的病史与不同的海马亚区中较低的血容量显着相关，这可能是更广泛治疗的结果。这可能表明MC后CA-2 / 3的特定萎缩，并应在较大的人群中激发海马亚野评估。