Asthma is a chronic allergic inflammatory disease of the airways. The symptoms can be controlled by inhaled corticosteroids together with long-acting β2 agonists in the majority of patients; however, in some patients, their symptoms remain uncontrolled even under intensive treatment. Although underlying mechanisms of the heterogeneous responses to the treatment are largely unknown, a series of recent epidemiological studies have suggested a link between the severity of asthma and the sensitization to fungi. Dectin-1, a C-type lectin receptor expressed on myeloid cells and plays protective roles against fungi by recognizing a cell-wall component of fungi, has recently been suggested to be involved in the development of severe asthma. In this review, we summarize the roles of Dectin-1 in the pathogenesis of severe asthma and discuss the possibility of its therapeutic application.

中文翻译：

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Dectin-1在过敏性气道炎症中的作用。

哮喘是气道的慢性过敏性炎症。在大多数患者中，吸入糖皮质激素和长效β2激动剂可以控制症状。但是，在某些患者中，即使接受强化治疗，其症状仍无法控制。尽管对治疗的异质反应的潜在机制尚不清楚，但最近的一系列流行病学研究表明，哮喘的严重程度与对真菌的敏感性之间存在联系。Dectin-1是一种在髓样细胞上表达的C型凝集素受体，通过识别真菌的细胞壁成分而对真菌起保护作用，最近有人提出它参与了严重哮喘的发展。在这篇评论中