Mixed evidence exists regarding the role of N-methyl-D-aspartate (NMDA) receptors in memory reconsolidation. We provide no evidence that NMDA receptors are involved with memory reconsolidation, but instead demonstrate that prereactivation systemic MK-801 injection, combined with postreactivation intrabasolateral amygdala (BLA) cycloheximide infusion, produces a delayed potentiation of extinction learning. These data suggest that an interaction between NMDA antagonism and protein synthesis inhibition may enhance extinction by exerting effects outside of the intended reconsolidation manipulation window. The present work demonstrates a novel pharmacological enhancement of extinction, and underscores the importance of employing proper control procedures in reconsolidation research. (PsycINFO Database Record

中文翻译：

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MK-801和环己酰亚胺的联合给药产生恐惧歧视记忆消失的延迟增强。

关于N-甲基-D-天冬氨酸（NMDA）受体在记忆重建中的作用，存在混合的证据。我们没有提供任何证据表明NMDA受体与记忆重建有关，而是证明了再活化前全身性MK-801注射与再活化后基底外侧杏仁核（BLA）环己酰亚胺的输注相结合，会导致灭绝学习的延迟增强。这些数据表明，NMDA拮抗作用和蛋白质合成抑制作用之间的相互作用可能会通过在预期的重组操作窗口之外发挥作用而增强灭绝作用。本工作证明了灭绝的一种新的药理作用，并强调了在巩固研究中采用适当控制程序的重要性。（PsycINFO数据库记录