Diterpenoid alkaloids with remarkable chemical properties and biological activities are frequently found in plants of the genera Aconitum, Delphinium, and Garrya. Accordingly, several C19-diterpenoid alkaloid components from Delphinium elatum cv. Pacific Giant, as well as their derivatives, exhibited cytotoxic activity against lung, prostate, nasopharyngeal, and vincristine-resistant nasopharyngeal cancer cell lines. Four new C19-diterpenoid alkaloids, elapacigine (1), N-deethyl-N-formylpaciline (2), N-deethyl-N-formylpacinine (3), and N-formyl-4,19-secoyunnadelphinine (4), together with 11 known C19-diterpenoid alkaloids were isolated in a phytochemical investigation on the seeds of D. elatum cv. Pacific Giant. Their structures were elucidated by extensive spectroscopic methods including NMR (1D and 2D), IR, and MS (HRMS). Three of the new C19-diterpenoid alkaloids (2-4) and five of the known diterpenoid alkaloids were evaluated for cytotoxic activity against five human tumor cell lines.

中文翻译：

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来自翠雀属的四种新的C19-二萜生物碱。

具有显着化学性质和生物活性的二萜类生物碱经常在乌头属，翠雀属和嘉莉亚属的植物中发现。因此，来自翠雀（delphinium elatum）cv的几种C19-二萜生物碱组分。太平洋巨人及其衍生物对肺，前列腺，鼻咽和长春新碱耐药的鼻咽癌细胞系表现出细胞毒活性。四个新的C19-二萜生物碱，依拉帕金（1），N-去乙基-N-甲酰基paciline（2），N-去乙基-N-甲酰基pacinine（3）和N-甲酰基-4,19-secoyunnadelphinine（4）在D. elatum cv种子的植物化学研究中，分离出11种已知的C19-二萜生物碱。太平洋巨人。通过包括NMR（1D和2D），IR和MS（HRMS）在内的广泛光谱方法阐明了它们的结构。