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Efficient fluorescence detection of aromatic toxicants and toxicant metabolites in human breast milk
Supramolecular Chemistry ( IF 3.3 ) Pub Date : 2017-07-03 , DOI: 10.1080/10610278.2017.1343947
Dana J DiScenza 1 , Julie Lynch 1 , Molly Verderame 1 , Nicole Serio 2 , Lindsey Prignano 3 , Lauren Gareau 4 , Mindy Levine 1
Affiliation  

Abstract Once chemical contaminants are released into the environment, there are a number of concerns that arise regarding the environmental persistence of the contaminants, their known and suspected toxicities, and their potential disruption to the ecosystem. One class of contaminants that is of continuing concern is polycyclic aromatic hydrocarbons (PAHs), persistent organic pollutants that are significant components of oil spills. PAHs have been found in the breast milk of nursing mothers living in oil spill-affected regions, and can harm the nursing children. We report herein the sensitive and selective detection of 10 PAHs and PAH metabolites in human breast milk using fluorescence energy transfer from the PAH to a high quantum yield fluorophore, and array-based statistical analyses of the resulting fluorescence responses. This detection system was able to separate and identify the PAHs with 100% success in human breast milk and at concentrations as low as 0.17 μM. These results have significant implications in public health and in the monitoring and mitigation of environmental disasters.

中文翻译:

人母乳中芳香族毒物和毒物代谢物的高效荧光检测

摘要 一旦化学污染物释放到环境中,人们就会担心污染物的环境持久性、已知和可疑的毒性以及对生态系统的潜在破坏。持续受到关注的一类污染物是多环芳烃 (PAH),这是一种持久性有机污染物,是石油泄漏的重要组成部分。生活在石油泄漏影响地区的哺乳期母亲的母乳中发现了多环芳烃,它可能会伤害哺乳期的儿童。我们在此报告了利用从 PAH 到高量子产率荧光团的荧光能量转移,对人母乳中 10 种 PAH 和 PAH 代谢物进行灵敏和选择性检测,并对所得荧光响应进行基于阵列的统计分析。该检测系统能够 100% 成功地分离和识别母乳中的 PAH,且浓度低至 0.17 μM。这些结果对公共卫生以及环境灾害的监测和减轻具有重大影响。
更新日期:2017-07-03
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