Predicting 3D structure of protein from its amino acid sequence is one of the most important unsolved problems in biophysics and computational biology. This paper attempts to give a comprehensive introduction of the most recent effort and progress on protein structure prediction. Following the general flowchart of structure prediction, related concepts and methods are presented and discussed. Moreover, brief introductions are made to several widely-used prediction methods and the community-wide critical assessment of protein structure prediction (CASP) experiments.

中文翻译：

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蛋白质结构预测

从氨基酸序列预测蛋白质的 3D 结构是生物物理学和计算生物学中最重要的未解决问题之一。本文试图全面介绍蛋白质结构预测的最新成果和进展。按照结构预测的总体流程图，介绍并讨论了相关概念和方法。此外，还简要介绍了几种广泛使用的预测方法和全界蛋白质结构预测（CASP）实验的关键评估。