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Behavioral models in psychopathology: epistemic and semantic considerations.
Behavioral and Brain Functions ( IF 5.1 ) Pub Date : 2019-03-01 , DOI: 10.1186/s12993-019-0152-4
Caio Maximino 1 , Franz Josef van der Staay 2
Affiliation  

The use of animals in neurosciences has a long history. It is considered indispensable in areas in which "translational" research is deemed invaluable, such as behavioral pharmacology and comparative psychology. Animal models are being used in pharmacology and genetics to screen for treatment targets, and in the field of experimental psychopathology to understand the neurobehavioral underpinnings of a disorder and of its putative treatment. The centrality of behavioral models betrays the complexity of the epistemic and semantic considerations which are needed to understand what a model is. In this review, such considerations are made, and the breadth of model building and evaluation approaches is extended to include theoretical considerations on the etiology of mental disorders. This expansion is expected to help improve the validity of behavioral models and to increase their translational value. Moreover, the role of theory in improving construct validity creates the need for behavioral scientists to fully engage this process.

中文翻译:

心理病理学中的行为模型:认知和语义方面的考虑。

在神经科学中使用动物已有很长的历史。在“翻译”研究被认为无价的领域,例如行为药理学和比较心理学,它被认为是必不可少的。动物模型正在药理和遗传学中用于筛选治疗靶标,在实验性精神病理学领域中正在使用该模型来了解疾病及其推定治疗的神经行为基础。行为模型的中心性出卖了认知和语义方面的复杂性,这是理解模型是必需的。在这篇综述中,进行了这样的考虑,并且扩展了模型构建和评估方法的范围,以包括关于精神障碍病因的理论考虑。预期这种扩展将有助于提高行为模型的有效性并增加其转换价值。此外,理论在提高建构效度方面的作用产生了行为科学家充分参与这一过程的需求。
更新日期:2020-04-22
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