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NFAT5 Has a Job in the Brain.
Developmental Neuroscience ( IF 2.9 ) Pub Date : 2018-11-06 , DOI: 10.1159/000493789
Xing-Liang Yang 1 , Xin Wang 1 , Bi-Wen Peng 2
Affiliation  

Nuclear factor of activated T cells 5 (NFAT5) has recently been classified as a new member of the Rel family. In addition, there are 5 more well-defined members (NF-κB and NFAT1-4) in the Rel family, which participate in regulating the expression of immune and inflammatory response-related genes. NFAT5 was initially identified in renal medullary cells where it regulated the expression of osmoprotective-related genes during the osmotic response. Many studies have demonstrated that NFAT5 is highly expressed in the nuclei of neurons in fetal and adult brains. Additionally, its expression is approximately 10-fold higher in fetal brains. With the development of detection technologies (laser scanning confocal microscopy, transgene technology, etc.), recent studies suggest that NFAT5 is also expressed in glial cells and plays a more diverse functional role. This article aims to summarize the current knowledge regarding the expression of NFAT5, its regulation of activation, and varied biological functions in the brain.

中文翻译:

NFAT5在大脑中有工作。

激活的T细胞5(NFAT5)的核因子最近已被分类为Rel家族的新成员。此外,Rel家族中还有5个定义明确的成员(NF-κB和NFAT1-4),它们参与调节免疫和炎症反应相关基因的表达。NFAT5最初是在肾髓质细胞中发现的,它在渗透反应过程中调节与渗透保护有关的基因的表达。许多研究表明,NFAT5在胎儿和成年大脑的神经元核中高度表达。此外,它在胎儿脑中的表达高约10倍。随着检测技术(激光扫描共聚焦显微镜,转基因技术等)的发展,最近的研究表明,NFAT5在神经胶质细胞中也有表达,并起着更加多样化的功能作用。本文旨在总结有关NFAT5的表达,其对激活的调节以及大脑中各种生物学功能的最新知识。
更新日期:2019-11-01
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