The search for a nontoxic radioprotector has not yielded any promising results. Many antioxidant compounds, though effective under in vitro conditions as radioprotectors, have failed under in vivo settings due to their toxicity. The Indian medical system of Ayurveda uses a variety of plants with antioxidant potential, and these may be harboring molecules with radioprotective properties. In the present work, the radioprotective property of Nardostachys jatamansi was investigated. A hydro-alcoholic extract of this plant provided protection to the cellular DNA and membrane from 4 Gy gamma radiation. Depletion of cellular antioxidant status was also prevented by this extract. Molecular-level analysis in the intestines of mice revealed a lower bax/bcl2 ratio suggestive of a reduction of radiation-induced apoptosis. Expression levels of the DNA repair gene atm were elevated, along with a reduction in the expression of the inflammatory gene cox2. The extract also provided a survival advantage to mice exposed to lethal doses of gamma radiation. These results suggest a possible radioprotective role for Nardostachys jatamansi.

中文翻译：

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Natastachys jatamansi的酒精提取物减少了伽玛射线引起的伤害。

寻找无毒的辐射防护剂并未产生任何有希望的结果。尽管许多抗氧化剂化合物在体外条件下可作为放射防护剂有效，但由于其毒性而在体内条件下失效。印度阿育吠陀医学系统使用具有抗氧化潜力的多种植物，这些植物可能带有具有辐射防护特性的分子。在目前的工作中，研究了Nardostachys jatamansi的辐射防护性能。该植物的水醇提取物为细胞DNA和膜提供了4 Gyγ射线的保护。该提取物还防止了细胞抗氧化剂状态的消耗。小鼠肠道中的分子水平分析显示较低的bax / bcl2比值表明放射诱导的细胞凋亡减少。DNA修复基因atm的表达水平升高，同时炎症基因cox2的表达降低。该提取物还为暴露于致死剂量的伽马射线辐射的小鼠提供了生存优势。这些结果表明Nardostachys jatamansi可能具有辐射防护作用。