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Lessons from the Barn to the Operating Suite: A Comprehensive Review of Animal Models for Fetal Surgery.
Annual Review of Animal Biosciences ( IF 12.0 ) Pub Date : 2017-12-14 , DOI: 10.1146/annurev-animal-030117-014637
Sandra K Kabagambe 1 , Chelsey J Lee 1 , Laura F Goodman 1 , Y Julia Chen 1 , Melissa A Vanover 1 , Diana L Farmer 1
Affiliation  

The International Fetal Medicine and Surgery Society was created in 1982 and proposed guidelines for fetal interventions that required demonstrations of the safety and feasibility of intended interventions in animal models prior to application in humans. Because of their short gestation and low cost, small animal models are useful in early investigation of fetal strategies. However, owing to the anatomic and physiologic differences between small animals and humans, repeated studies in large animal models are usually needed to facilitate translation to humans. Ovine (sheep) models have been used the most extensively to study the pathophysiology of congenital abnormalities and to develop techniques for fetal interventions. However, nonhuman primates have uterine and placental structures that most closely resemble those of humans. Thus, the nonhuman primate is the ideal model to develop surgical and anesthetic techniques that minimize obstetrical complications.

中文翻译:

从谷仓到手术室的经验:胎儿外科动物模型的全面综述。

国际胎儿医学和外科学会成立于1982年,提出了胎儿干预措施的指导原则,要求在动物模型应用于人之前证明动物干预措施的安全性和可行性。由于其短期妊娠和低成本,小型动物模型可用于胎儿策略的早期研究。然而,由于小动物和人类之间在解剖学和生理上的差异,通常需要在大动物模型中进行重复研究以促进向人类的翻译。绵羊(绵羊)模型已被最广泛地用于研究先天性异常的病理生理学并开发用于胎儿干预的技术。但是,非人类的灵长类动物的子宫和胎盘结构与人类的最相似。从而,
更新日期:2019-11-01
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