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Structural Biology of the Major Facilitator Superfamily Transporters.
Annual Review of Biophysics ( IF 12.4 ) Pub Date : 2015-06-23 , DOI: 10.1146/annurev-biophys-060414-033901
Nieng Yan 1
Affiliation  

The ancient and ubiquitous major facilitator superfamily (MFS) represents the largest secondary transporter family and plays a crucial role in a multitude of physiological processes. MFS proteins transport a broad spectrum of ions and solutes across membranes via facilitated diffusion, symport, or antiport. In recent years, remarkable advances in understanding the structural biology of the MFS transporters have been made. This article reviews the history, classification, and general features of the MFS proteins; summarizes recent structural progress with a focus on the sugar porter family transporters exemplified by GLUT1; and discusses the molecular mechanisms of substrate binding, alternating access, and cotransport coupling.

中文翻译:

主要促进者超家族转运蛋白的结构生物学。

古代无处不在的主要促进者超家族(MFS)代表着最大的二级转运蛋白家族,在众多生理过程中起着至关重要的作用。MFS蛋白通过促进扩散,同向转运或逆向转运,将各种离子和溶质跨膜运输。近年来,在了解MFS转运蛋白的结构生物学方面取得了显着进步。本文回顾了MFS蛋白的历史,分类和一般特征;总结了最近的结构进展,重点是以GLUT1为例的糖搬运工系列转运蛋白。并讨论了底物结合,交替进入和共转运偶联的分子机理。
更新日期:2015-06-22
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