Background

Ectopic lipids such as intramyocellular lipids (IMCL) are depleted by exercise and repleted by diet, whereas intrahepatocellular lipids (IHCL) are increased immediately after exercise. So far, it is unclear how ectopic lipids behave 24 h after exercise and whether the lack of growth hormone (GH) significantly affects ectopic lipids 24 h after exercise.

Methods

Seven male patients with growth hormone deficiency (GHD) and seven sedentary male control subjects (CS) were included. VO_2max was assessed by spiroergometry; visceral and subcutaneous fat by whole body MRI. ¹H-MR-spectroscopy was performed in M. vastus intermedius and in the liver before and after 2 h of exercise at 50% VO_2max and 24 h thereafter, while diet and physical activity were standardized.

Results

Sedentary male subjects (7 GHD, 7 CS) were recruited. Age, BMI, waist circumference, visceral and subcutaneous fat mass was not significantly different between GHD and CS. VO_2max was significantly lower in GHD vs. CS. IMCL were diminished through aerobic exercise in both groups: (−11.5 ± 21.9% in CS; −8.9% ±19.1% in GHD) and restored after 24 h in CS (−5.5 ± 26.6% compared to baseline) but not in GHD (−17.9 ± 15.3%). IHCL increased immediately after exercise and decreased to baseline within 24 h.

Conclusion

These findings suggest that GHD may affect repletion of IMCL 24 h after aerobic exercise.

中文翻译：

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一轮有氧运动后生长激素缺乏症患者的肌内脂质补充受损。

背景

运动后消耗了异位脂质，如肌细胞内脂质（IMCL），饮食也使饮食补充了异位脂质，而运动后立即肝内细胞内脂质（IHCL）增加。到目前为止，还不清楚运动后24小时异位脂质的行为，运动后24小时缺乏生长激素（GH）是否会显着影响异位脂质。

方法

包括七名患有生长激素缺乏症（GHD）的男性患者和七名久坐的男性对照受试者（CS）。VO _2max通过旋光法测定；全身MRI检查内脏和皮下脂肪。¹ H-MR光谱法在运动前后2 h以50％VO _2max和之后24 h在中间支原体和肝脏中进行，同时饮食和身体活动已标准化。

结果

征募了久坐的男性受试者（7 GHD，7 CS）。GHD和CS之间的年龄，BMI，腰围，内脏和皮下脂肪量没有显着差异。GHD的VO _2max明显低于CS。两组的有氧运动使IMCL降低：（CS -11.5±21.9％； GHD -18.9％±19.1％），CS 24小时后恢复（与基线相比−5.5±26.6％），但在GHD中没有恢复（ -17.9±15.3％）。运动后IHCL立即升高，并在24小时内降至基线。

结论

这些发现表明，有氧运动后24小时GHD可能会影响IMCL的补充。