Paracoccidioidomycosis (Pm) is a systemic disease, endemic in the American continent. There are two different clinical forms, the infant-juvenile or subacute form (PmS) and the chronic adult form (PmC). The human immunodeficiency virus (HIV) associated paracoccidioidomycosis (PmHIV) shares characteristics with both of the previously mentioned forms. The objective of this work was to describe the epidemiological, clinical and laboratory features of the PmHIV and to compare them with the ones of PmS and the PmC. A retrospective analysis of 119 patients with paracoccidioidomycosis was performed. Ninety four suffered the chronic form, 11 the subacute one and 14 were coinfected with HIV. Patients with PmHIV presented a CD4+ T lymphocytes median of 70.5 cells/μl, 71.4% had fever, 64.3% had a miliary pattern on the chest radiography, 64.3% had hepatosplenomegaly, 64.3% had mucosal lesions and 50% had skin lesions. One patient died during his hospitalization. The clinical presentation of Pm in patients with HIV resembled the subacute form with fever, hepatomegaly and skin lesions. However, they also tended to present mucosal lesions, positive serology for Pm and pulmonary parenchyma lesions as usually seen in PmC (9/14 PmHIV patients had overlapping features, while 4/14 PmHIV patients clinically resembled PmS and 1/14 PmC). The incidence of Pm has not changed with the burden of AIDS as it has happened with other fungal infections but it appears clinically different from the classic clinical forms of the disease.

中文翻译：

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阿根廷布宜诺斯艾利斯的艾滋病患者副球菌类真菌病的临床和微生物学特征。

副球菌病（Pm）是一种系统性疾病，在美洲大陆流行。有两种不同的临床形式，婴幼儿或亚急性形式（PmS）和慢性成人形式（PmC）。人类免疫缺陷病毒（HIV）相关的副球菌类真菌病（PmHIV）具有上述两种形式的特征。这项工作的目的是描述PmHIV的流行病学，临床和实验室特征，并将其与PmS和PmC进行比较。回顾性分析了119名副球菌病患者。九十四名患有慢性病，十一名亚急性感染者和十四名感染了艾滋病毒。PmHIV患者的CD4 + T淋巴细胞中位数为70.5个细胞/微升，71.4％的患者发烧，64.3％的患者在胸部X线照片上出现粟粒型，64。肝脾肿大的占3％，粘膜病变的占64.3％，皮肤病变的占50％。一名患者在住院期间死亡。HIV患者中Pm的临床表现类似于发烧，肝肿大和皮肤病变的亚急性形式。然而，他们也倾向于表现出粘膜病变，Pm血清学阳性和肺实质病变，这在PmC中通常可见（9/14 PmHIV患者具有重叠特征，而4/14 PmHIV患者在临床上类似于PmS和1/14 PmC）。Pm的发生率并没有像其他真菌感染那样随着AIDS的负担而改变，但在临床上似乎与该疾病的经典临床形式不同。HIV患者中Pm的临床表现类似于发烧，肝肿大和皮肤病变的亚急性形式。然而，他们也倾向于表现出粘膜病变，Pm血清学阳性和肺实质病变，这在PmC中通常可见（9/14 PmHIV患者具有重叠特征，而4/14 PmHIV患者在临床上类似于PmS和1/14 PmC）。Pm的发生率并没有像其他真菌感染那样随着AIDS的负担而改变，但在临床上似乎与该疾病的经典临床形式不同。HIV患者中Pm的临床表现类似于发烧，肝肿大和皮肤病变的亚急性形式。然而，他们也倾向于表现出粘膜病变，Pm血清学阳性和肺实质病变，这在PmC中通常可见（9/14 PmHIV患者具有重叠特征，而4/14 PmHIV患者在临床上类似于PmS和1/14 PmC）。Pm的发生率并没有像其他真菌感染那样随着AIDS的负担而改变，但在临床上似乎与该疾病的经典临床形式不同。而4/14 PmHIV患者在临床上与PmS和1/14 PmC类似。Pm的发生率并没有像其他真菌感染那样随艾滋病的负担而改变，但是在临床上看来与该疾病的经典临床形式不同。而4/14 PmHIV患者在临床上与PmS和1/14 PmC类似。Pm的发生率并没有像其他真菌感染那样随着AIDS的负担而改变，但在临床上似乎与该疾病的经典临床形式不同。