OBJECTIVE Accumulation of adipose tissue is associated with cardiometabolic risks. Although visceral adipose tissue (VAT) has been strongly implicated in this relationship, there is still some debate regarding the contribution of abdominal subcutaneous adipose tissue (SAT). The purpose of this study was to determine the contribution of abdominal SAT to cardiometabolic risk factors, independent of total and visceral adiposity. These relationships were assessed in Caucasian and African Americans. DESIGN It is a cross-sectional analysis of the Pennington Center Longitudinal Study. SUBJECTS Data were extracted from 1246 participants. Total body fat mass (FM) was measured by dual-energy X-ray absorptiometry, whereas abdominal VAT and SAT areas (cm(2)) were measured with computed tomography. The cardiometabolic risk factors included resting blood pressure (BP), fasting blood glucose and triglyceride concentrations and high-density lipoprotein cholesterol (HDL-C). RESULTS Positive relationships across tertiles of VAT were seen for the participants with high glucose, high BP and low HDL-C (P<0.043). There was also a significant increase in the percentage of participants with two or more cardiometabolic risk factors across most tertiles of abdominal SAT (P<0.042). Logistic regression analysis showed that in univariate models, all adiposity measures were significantly associated with increased odds of having all risk factors in men and women. In multivariate models, VAT was significantly associated with most risk factors across gender. Abdominal SAT and FM (odds ratios (ORs) 1.3-2.1; all P<0.05) were associated with fewer risk factors after accounting for VAT. VAT (OR=5.9 and 5.3) and SAT (OR=2.0 and 1.8) were both associated with higher odds of the presence of two or more cardiometabolic risk factors in both males and females (P<0.001). CONCLUSION The data suggest that abdominal SAT is not protective against unfavorable cardiometabolic risk profiles. These conclusions were consistent across ethnic groups.

中文翻译：

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腹部脂肪堆积与白种人和非裔美国成年人的心脏代谢不良风险因素相关。

目的 脂肪组织的积累与心脏代谢风险有关。尽管内脏脂肪组织 (VAT) 与这种关系密切相关，但关于腹部皮下脂肪组织 (SAT) 的贡献仍存在一些争论。本研究的目的是确定腹部 SAT 对心脏代谢危险因素的影响，独立于总肥胖和内脏肥胖。这些关系在白种人和非裔美国人中进行了评估。设计 这是彭宁顿中心纵向研究的横断面分析。主题 从 1246 名参与者中提取数据。全身脂肪量 (FM) 是用双能 X 射线吸收测定法测量的，而腹部增值税和 SAT 区域 (cm(2)) 是用计算机断层扫描测量的。心脏代谢危险因素包括静息血压 (BP)、空腹血糖和甘油三酯浓度以及高密度脂蛋白胆固醇 (HDL-C)。结果 在高血糖、高血压和低 HDL-C 的参与者中，VAT 的三分位数呈正相关（P<0.043）。在腹部SAT的大多数三分位数中，具有两个或更多心脏代谢危险因素的参与者百分比也显着增加（P<0.042）。Logistic 回归分析表明，在单变量模型中，所有肥胖指标都与男性和女性具有所有危险因素的几率增加显着相关。在多变量模型中，增值税与大多数性别风险因素显着相关。腹部 SAT 和 FM（优势比 (OR) 1.3-2.1；所有 P < 0。05) 在计入增值税后与较少的风险因素相关。VAT（OR=5.9 和 5.3）和 SAT（OR=2.0 和 1.8）都与男性和女性存在两种或多种心脏代谢风险因素的较高几率相关（P<0.001）。结论 数据表明，腹部 SAT 对不利的心脏代谢风险特征没有保护作用。这些结论在不同种族群体中是一致的。