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Highly Functionalized Ring B Labdane Synthesis as Key Intermediate in the Route to Forskolin.
Natural Product Communications ( IF 1.8 ) Pub Date : 2017-05-01
Ignacio E Tobal , Lourdes Castañeda , Alejandro M Roncero , Rosalina F Moro , David Diez , Isidro S Marcos

Sclareol has been employed as starting material for the synthesis of several advanced intermediates towards the synthesis of highly ring B oxygenated labdanes. Dinorlabdanes 6,7,8,9-tetraoxygenated with 6,7-dioxygenated functionalities with a-cis or O-cis dispositions, have been prepared and can be used for forskolin or analogues synthesis.

中文翻译:

高度功能化的环B Labdane合成是通往佛司可林的关键中间体。

香紫苏已被用作起始原料,用于合成一些高级中间体,以合成高度环B的氧化拉丹烷。已经制备了具有6,7-双加氧官能团且具有α-顺式或O-顺式位置的二去氧丹烯6,7,8,9-四加氧,并且可用于毛喉素或类似物的合成。
更新日期:2019-11-01
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