The chemokine CXCL12 plays a vital role in regulating the development of the central nervous system (CNS) by binding to its receptors CXCR4 and CXCR7. Recent studies reported that the CXCL12/CXCR4/CXCR7 axis regulates both embryonic and adult oligodendrocyte precursor cells (OPCs) in their proliferation, migration, and differentiation. The changes in the expression and distribution of CXCL12 and its receptors are tightly associated with the pathological process of demyelination in multiple sclerosis (MS), suggesting that modulating the CXCL12/CXCR4/CXCR7 axis may benefit myelin repair by enhancing OPC recruitment and differentiation. This review aims to integrate the current findings of the CXCL12/CXCR4/CXCR7 signaling pathway in the CNS and to highlight its role in oligodendrocyte development and demyelinating diseases. Furthermore, this review provides potential therapeutic strategies for myelin repair by analyzing the relevance between the pathological changes and the regulatory roles of CXCL12/CXCR4/CXCR7 during MS.

中文翻译：

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中枢神经系统中的CXCL12 / CXCR4 / CXCR7趋化因子轴：脱髓鞘疾病中髓鞘再生的治疗目标。

趋化因子CXCL12通过与其受体CXCR4和CXCR7结合，在调节中枢神经系统（CNS）的发育中起着至关重要的作用。最近的研究报道，CXCL12 / CXCR4 / CXCR7轴可调节胚胎和成年少突胶质前体细胞（OPC）的增殖，迁移和分化。CXCL12及其受体表达和分布的变化与多发性硬化症（MS）脱髓鞘的病理过程密切相关，这表明调节CXCL12 / CXCR4 / CXCR7轴可能通过增强OPC募集和分化而有益于髓鞘修复。这篇综述旨在整合CXCL12 / CXCR4 / CXCR7信号通路在中枢神经系统中的最新发现，并突出其在少突胶质细胞发育和脱髓鞘疾病中的作用。此外，