The increased use of nanosized materials is likely to result in the release of these particles into the environment. It is, however, unclear if these materials are harmful to aquatic animals. In this study, the sublethal effects of exposure of low and high concentrations of titanium dioxide nanoparticles (TiO₂ NPs) on goldfish (Carassius auratus) were investigated. Accumulation of TiO₂ NPs increased from 42.71 to 110.68 ppb in the intestine and from 4.10 to 9.86 ppb in the gills of the goldfish with increasing exposure dose from 10 to 100 mg/L TiO₂ NPs. No significant accumulation in the muscle and brain of the fish was detected. Malondialdehyde as a biomarker of lipid oxidation was detected in the liver of the goldfish. Moreover, TiO₂ NPs exposure inhibited growth of the goldfish. Although there was an increase (8.1%) in the body weights of the goldfish for the control group, in the low and high exposure groups 1.8% increase and 19.7% decrease were measured, respectively. The results of this study contribute to the current understanding of the potential ecotoxicological effects of nanoparticles and highlight the importance of characterization of NPs in understanding their behavior, uptake, and effects in aquatic systems and in fish.

中文翻译：

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工程化二氧化钛（TiO2）纳米颗粒在金鱼（Car鱼）中的生物蓄积，亚急性毒性和组织分布。

纳米材料的增加使用可能导致这些颗粒释放到环境中。但是，尚不清楚这些材料是否对水生动物有害。在这项研究中，研究了低和高浓度二氧化钛纳米颗粒（TiO ₂ NPs）暴露于金鱼（Carassius auratus）的亚致死作用。随着暴露剂量从10 mg / L TiO ₂增加到100 mg / L，金鱼g中肠内TiO ₂ NP的累积量从42.71 ppb增加到110.68 ppb，从and鱼的4.10 pp。增加到9.86 ppb。NP。在鱼的肌肉和大脑中未发现明显的积累。在金鱼的肝脏中检测到丙二醛作为脂质氧化的生物标记。此外，TiO ₂ NPs暴露抑制了金鱼的生长。尽管对照组的金鱼体重增加了（8.1％），但在低暴露和高暴露组中，分别测得金鱼的体重增加了1.8％和减少了19.7％。这项研究的结果有助于当前对纳米颗粒潜在的生态毒理学作用的了解，并突出了NP表征对了解其在水生系统和鱼类中的行为，摄取及其影响的重要性。