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LncRNAs: Potential Novel Prognostic and Diagnostic Biomarkers in Colorectal Cancer.
Current Medicinal Chemistry ( IF 4.1 ) Pub Date : 2020-08-31 , DOI: 10.2174/0929867326666190227230024
Narges Dastmalchi 1 , Reza Safaralizadeh 1 , Mirsaed Miri Nargesi 2
Affiliation  

Background: Long non-coding RNAs (lncRNAs), a type of regulatory RNAs, play a key role in numerous cellular pathways. Ectopic expression of this group of non-coding RNAs has been specified to be involved in numerous diseases. Moreover, the role of lncRNAs in the initiation and development of cancers including colorectal cancer (CRC) has been acknowledged.

Objective: In the present review, the role of lncRNAs as prognostic and diagnostic biomarkers in CRC as well as the molecular mechanisms of their contribution to development of CRC has been addressed.

Results: The presented studies have indicated the ectopic expression of various lncRNAs in CRC. Some lncRNAs which were considered as tumor suppressors were downregulated in the colorectal cancerous tissues compared with healthy controls; however, some with oncogenic effects were upregulated. LncRNAs contribute to tumor development via various molecular mechanisms such as epigenetically controlling the expression of target genes, interacting with miRNAs as their sponge, etc.

Conclusion: LncRNAs that have been recognized as prognostic biomarkers may pave the way for clinical management to offer adjuvant treatments for patients with CRC.



中文翻译:

LncRNA:在结直肠癌中潜在的新型预后和诊断生物标志物。

背景:长非编码RNA(lncRNA)是一种调节性RNA,在众多细胞途径中起着关键作用。已指定这组非编码RNA的异位表达与多种疾病有关。此外,已经确认lncRNA在包括结直肠癌(CRC)的癌症的引发和发展中的作用。

目的:在本综述中,lncRNAs在CRC中作为预后和诊断生物标志物的作用及其对CRC形成贡献的分子机制已得到解决。

结果:目前的研究表明CRC中各种lncRNA的异位表达。与健康对照组相比,一些被认为是抑癌基因的lncRNA在大肠癌组织中被下调。然而,一些具有致癌作用的基因被上调。LncRNA通过多种分子机制(例如表观遗传学控制靶基因的表达,与miRNA作为其海绵相互作用)来促进肿瘤的发展。

结论:被认为是预后生物标志物的LncRNA可能为临床管理铺平道路,为CRC患者提供辅助治疗。

更新日期:2020-09-08
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