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Preventing Peanut Allergy.
Pediatric Allergy, Immunology, and Pulmonology ( IF 0.9 ) Pub Date : 2018-03-29 , DOI: 10.1089/ped.2017.0826
Meng Chen 1 , Michael Welch 2, 3 , Susan Laubach 2, 3, 4
Affiliation  

The rising prevalence of food allergy and specifically peanut allergy has had significant implications for affected patients, families, and society. The current standard of care remains strict avoidance and the use of emergency medications for accidental ingestions. There is recent evidence-based information to suggest that one approach to preventing peanut allergy lies in early introduction of peanut. This represents a paradigm shift from previous recommendations and has led to updated guidelines in the United States, Europe, and Australasia on the introduction of potentially allergenic foods in the infant diet. This new approach to prevention has some practical obstacles and challenges associated with its implementation. There is also growing interest in the role of maintaining a healthy skin barrier in prevention of sensitization and food allergy. Other approaches, including pro- and prebiotics, prenatal maternal dietary avoidance, breastfeeding, and the use of specific formulas, have not shown reproducibly favorable results. As children with peanut allergy are unlikely to outgrow their food allergy, early oral immunotherapy in those with established peanut allergy is being investigated with the hopes of altering the natural history of an otherwise lifelong disease.

中文翻译:

预防花生过敏。

食物过敏,特别是花生过敏的患病率上升对受影响的患者,家庭和社会产生了重大影响。当前的护理标准仍然是严格避免和意外摄入紧急药物的使用。最近有基于证据的信息表明,预防花生过敏的一种方法是尽早引入花生。这代表了先前建议的范式转变,并导致在美国,欧洲和大洋洲更新了有关在婴儿饮食中引入潜在致敏食品的指南。这种新的预防方法在实施中存在一些实际的障碍和挑战。保持健康的皮肤屏障在预防过敏和食物过敏方面的作用也越来越引起人们的关注。其他方法,包括益生元和益生元,避免产前产妇饮食,母乳喂养以及使用特定配方奶粉,均未显示出可重复的良好效果。由于患有花生过敏症的儿童不太可能超过其食物过敏症,因此正在研究对已建立花生过敏症的儿童进行早期口服免疫疗法,以期改变原本终生疾病的自然史。
更新日期:2019-11-01
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