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Photoacoustic imaging of gold nanorods in the brain delivered via microbubble-assisted focused ultrasound: a tool for in vivo molecular neuroimaging
Laser Physics Letters ( IF 1.7 ) Pub Date : 2019-01-17 , DOI: 10.1088/1612-202x/aaf89e
Robin K Hartman 1 , Kristina A Hallam 1, 2 , Eleanor M Donnelly 1 , Stanislav Y Emelianov 1, 2
Affiliation  

The protective barriers of the CNS present challenges during the treatment and monitoring of diseases. In particular, the blood brain barrier is a major hindrance to the delivery of imaging contrast agents and therapeutics to the brain. In this work, we use gas microbubble-assisted focused ultrasound to transiently open the blood brain barrier and locally deliver silica coated gold nanorods across the barrier. This particular nanoagent possesses a strong optical absorption which enables in vivo and ex vivo visualization of the delivered particles using ultrasound-guided photoacoustic imaging. The results of these studies demonstrate the potential of ultrasound-guided photoacoustics to image contrast agents delivered via microbubble-assisted focused ultrasound for longitudinal diagnostic imaging and for therapeutic monitoring of neurological diseases.

中文翻译:

通过微泡辅助聚焦超声对大脑中的金纳米棒进行光声成像:一种用于体内分子神经成像的工具

中枢神经系统的保护屏障在疾病的治疗和监测过程中提出了挑战。特别是,血脑屏障是将成像造影剂和治疗剂输送到大脑的主要障碍。在这项工作中,我们使用气体微泡辅助聚焦超声瞬时打开血脑屏障,并局部递送二氧化硅涂层的金纳米棒穿过屏障。这种特殊的纳米剂具有很强的光吸收性,可以使用超声引导的光声成像在体内和体外对递送的颗粒进行可视化。
更新日期:2019-01-17
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