Echinocandins, the lipopeptide class of glucan synthase inhibitors, are an alternative to ergosterol-synthesis inhibitors to treat candidiasis and aspergillosis. Their oral absorption, however, is low and they can only be used parenterally. During a natural product screening program for novel types of glucan synthesis inhibitors with improved bioavailability, a fungal extract was found that inhibited the growth of both a wild-type Saccharomyces cerevisiae strain and the null mutant of the FKS1 gene (fks1::HIS). The mutant strain was more sensitive to growth inhibition, suggesting that the fungal extract could contain an inhibitor of glucan synthesis. A novel acidic steroid, named arundifungin, was purified from a fungal extract obtained from a liquid culture of Arthrinium arundinis collected in Costa Rica. Arundifungin caused the same pattern of hallmark morphological alterations in Aspergillus fumigatus hyphae as echinocandins, further supporting the idea that arundifungin belongs to a new class of glucan synthesis inhibitors. Moreover, its antifungal spectrum was comparable to those of echinocandins and papulacandins, preferentially inhibiting the growth of Candida and Aspergillus strains, with very poor activity against Cryptococcus. Arundifungin was also detected in nine other fungal isolates which were ecologically and taxonomically unrelated, as assessed by sequencing of the ITS1 region. Further, it was also found in two more Arthrinium spp from tropical and temperate regions, in five psychrotolerant conspecific isolates collected on Macquarie Island (South Pacific) and belonging to the Leotiales, and in two endophytes collected in central Spain (a sterile fungus belonging to the Leotiales and an undetermined coelomycete).

中文翻译：

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Arundifungin，一种由真菌产生的新型抗真菌化合物：产生生物的生物活性和分类。

Echinocandins是葡聚糖合酶抑制剂的脂肽类，是麦角固醇合成抑制剂的替代品，可治疗念珠菌病和曲霉病。但是，它们的口服吸收率低，只能肠胃外使用。在对具有改善的生物利用度的新型葡聚糖合成抑制剂进行天然产物筛选的过程中，发现了一种真菌提取物，该提取物既抑制了野生型酿酒酵母菌株的生长，又抑制了FKS1基因的无效突变体（fks1:: HIS）。该突变株对生长抑制更为敏感，表明该真菌提取物可能含有葡聚糖合成抑制剂。一种新的酸性类固醇，命名arundifungin，由从的液体培养物中获得的真菌提取物中纯化节菱arundinis收集在哥斯达黎加。Arundifungin在烟曲霉菌丝中引起的形态特征与Echinocandins具有相同的特征，进一步支持了Arundifungin属于新型葡聚糖合成抑制剂的观点。此外，它的抗真菌谱与棘球and素和木瓜蛋白酶的谱图相当，优先抑制念珠菌和曲霉菌株的生长，其抗真菌活性很差。隐球菌。根据ITS1区域的测序评估，在其他9种在生态和分类学上均不相关的真菌分离物中也检测到了Arundifungin 。此外，也有人在两个发现节菱来自热带和温带地区属，在五个psychrotolerant同种菌株收集了麦夸里岛（南太平洋）和属于Leotiales，并在两个内生真菌收集在西班牙中部（无菌真菌属于Leotiales和未确定的腔肠菌）。