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Nanostructured Calcium-based Biomaterials and their Application in Drug Delivery.
Current Medicinal Chemistry ( IF 4.1 ) Pub Date : 2020-08-31 , DOI: 10.2174/0929867326666190222193357
Li-Juan Yi 1 , Jun-Feng Li 2 , Ming-Guo Ma 1 , Ying-Jie Zhu 3
Affiliation  

In the past several decades, various types of nanostructured biomaterials have been developed. These nanostructured biomaterials have promising applications in biomedical fields such as bone repair, tissue engineering, drug delivery, gene delivery, antibacterial agents, and bioimaging. Nanostructured biomaterials with high biocompatibility, including calcium phosphate, hydroxyapatite, and calcium silicate, are ideal candidates for drug delivery. This review article is not intended to offer a comprehensive review of the nanostructured biomaterials and their application in drug delivery but rather presents a brief summary of the recent progress in this field. Our recent endeavors in the research of nanostructured biomaterials for drug delivery are also summarized. Special attention is paid to the synthesis and properties of nanostructured biomaterials and their application in drug delivery with the use of typical examples. Finally, we discuss the problems and future perspectives of nanostructured biomaterials in the drug delivery field.



中文翻译:

纳米钙基生物材料及其在药物输送中的应用。

在过去的几十年中,已经开发了各种类型的纳米结构生物材料。这些纳米结构的生物材料在生物医学领域具有广阔的应用前景,例如骨修复,组织工程,药物递送,基因递送,抗菌剂和生物成像。具有高生物相容性的纳米结构生物材料,包括磷酸钙,羟基磷灰石和硅酸钙,是药物输送的理想选择。这篇综述文章无意对纳米结构生物材料及其在药物输送中的应用进行全面综述,而是简要概述了该领域的最新进展。还总结了我们最近在药物递送纳米结构生物材料研究中的努力。通过使用典型实例,对纳米结构生物材料的合成和性质及其在药物递送中的应用给予了特别关注。最后,我们讨论了纳米结构生物材料在药物输送领域中的问题和未来展望。

更新日期:2020-09-11
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