HIV drug resistance has been described in all antiretroviral drug classes and threatens the long-term success of HIV treatment. Here, we describe the first reported case of acquired resistance to the integrase strand transfer inhibitors in South Africa. This case illustrates the dilemma of treatment in the context of inadequate adherence and poor psychosocial support and highlights the potential risk of transmission of multidrug-resistant virus.

中文翻译：

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行的结尾？一例对三线抗逆转录病毒疗法耐药的病例。

HIV抗药性已在所有抗逆转录病毒药物类别中描述，并威胁到HIV治疗的长期成功。在这里，我们描述了南非首次报道的对整合酶链转移抑制剂产生抗药性的案例。该病例说明在依从性不足和心理社会支持差的情况下的治疗困境，并突出了传播耐多药病毒的潜在风险。