We report the case of an HIV-positive female patient with neurofibromatosis type 1 who was treated for recurrent peptic ulcer disease and later developed diabetes mellitus and chronic diarrhoea. A metastasising somatostatinoma was histologically proven and evidence of a concomitant gastrin-producing neuroendocrine tumour was found. Neuroendocrine tumours (NETs) are very rare neoplasms originating from a wide variety of endocrine and nervous system tissue with the ability to produce different hormones. A somatostatin- and gastrin-secreting NET in a patient with HIV has not been reported in the literature, to the best of our knowledge. We discuss oncogenic pathomechanisms related to the underlying conditions and propose stringent monitoring for tumours in HIV-positive patients with phakomatoses as well as initiation of antiretroviral therapy.

中文翻译：

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1型神经纤维瘤病和HIV患者的神经内分泌肿瘤。

我们报告了一名患有1型神经纤维瘤病的HIV阳性女性患者的病例，该患者接受了复发性消化性溃疡疾病的治疗，后来发展为糖尿病和慢性腹泻。在组织学上证明了转移性生长抑素瘤，并发现了伴随胃泌素产生的神经内分泌肿瘤的证据。神经内分泌肿瘤（NETs）是非常罕见的肿瘤，起源于各种各样的内分泌和神经系统组织，具有产生不同激素的能力。据我们所知，HIV病人中生长抑素和胃泌素分泌的NET尚未见报道。我们讨论了与潜在疾病相关的致癌机制，并建议严格监测艾滋病毒阳性患者的吞噬菌素以及开始抗逆转录病毒疗法。