Epigallocatechin gallate (EGCG) is a natural phenolic compound found in many plants, especially in green tea, which is a popular and restorative beverage with many claimed health benefits such as antioxidant, anti-cancer, anti-microbial, anti-diabetic, and anti-obesity activities. Despite its great curative potential, the poor bioavailability of EGCG restricts its clinical applcation. However, nanoformulations of EGCG are emerging as new alternatives to traditional formulations. This review focuses on the nanochemopreventive applications of various EGCG nanoparticles such as lipid-based, polymer-based, carbohydrate-based, protein-based, and metal-based nanoparticles. EGCG hybridized with these nanocarriers is capable of achieving advanced functions such as targeted release, active targeting, and enhanced penetration, ultimately increasing the bioavailability of EGCG. In addition, this review also summarizes the challenges for the use of EGCG in therapeutic applications, and suggests future directions for progress.

中文翻译：

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纳米化学疗法具有治疗益处：最新的综述集中在表没食子儿茶素没食子酸酯的递送上。

没食子儿茶素没食子酸酯（EGCG）是一种天然酚类化合物，存在于许多植物中，尤其是在绿茶中，绿茶是一种受欢迎的恢复性饮料，具有许多声称的健康益处，例如抗氧化剂，抗癌剂，抗微生物剂，抗糖尿病药和抗衰老药。肥胖活动。尽管其具有巨大的治疗潜力，但EGCG的生物利用度差限制了其临床应用。但是，EGCG的纳米配方正在作为传统配方的新替代品出现。这篇综述着重于各种EGCG纳米颗粒的纳米化学预防性应用，例如基于脂质的，基于聚合物的，基于碳水化合物的，基于蛋白质的和基于金属的纳米颗粒。与这些纳米载体杂交的EGCG能够实现高级功能，例如靶向释放，主动靶向和增强的穿透力，最终增加了EGCG的生物利用度。此外，本综述还总结了在治疗应用中使用EGCG的挑战，并提出了未来的发展方向。