In the present study, associations between pretreatment interleukin 6 (IL-6), interleukin 8 (IL-8) and C-reactive protein (CRP) serum levels and epithelial ovarian cancer (EOC) were analyzed using commercially available, enzyme-linked immunosorbent assay (ELISA) in 118 patients and 64 control subjects. Values were correlated with clinicopathological characteristics and outcomes. Control variables included age, stage, grade, histological type and residual tumor size. Kaplan-Meier plots and univariate and multivariate Cox proportional hazards models were used to study the associations between IL-6, IL-8 and CRP levels, control variables, overall survival and disease-free survival. The median IL-6, IL-8 and CRP serum levels in EOC were significantly higher than in the normal control group; 11.5 pg/mL (range, 3.4-62.6) versus 2.9 (1.1-12.3) pg/mL (p<0.001) and 21.8 pg/mL (range, 16.4-105.3) versus 9.3 (4.3-32.4) pg/mL (p<0.001) and 9.51 mg/L (range, 0.3-129.2) versus 1.2 (0.1-11.5) mg/L (p = 0.001), respectively. High levels of IL-6, IL-8 and CRP were associated with reduced overall survival (P = 0.003, P = 0.035, P = 0.046) and disease-free survival (P<0.001, P = 0.026, P = 0.043), respectively. Multivariate analyses showed that IL-6, IL-8 and CRP serum levels independently predicted disease-free survival (P = 0.011, P = 0.001 and P = 0.021), and overall survival (P = 0.004, P = 0.014 and P = 0.016), respectively. EOC is associated with extensive changes in the serum cytokine environment, highlighting the importance of further investigations of relative cytokine level changes. Preoperative serum IL-6, IL-8, and CRP levels seem promising for distinguishing EOC patients from healthy controls; however, their clinical value is still to be confirmed. High levels of IL-6, IL-8, and CRP in EOC patients have been suggested to be a poor prognostic factor for OS and DFS.

中文翻译：

---

血清IL-6，IL-8和CRP水平是上皮性卵巢癌的预后因素。

在本研究中，使用可商购的酶联免疫吸附剂分析了预处理白介素6（IL-6），白介素8（IL-8）和C反应蛋白（CRP）血清水平与上皮性卵巢癌（EOC）之间的关联。检测（118）的患者和64位对照对象。值与临床病理特征和结局相关。控制变量包括年龄，分期，等级，组织学类型和残余肿瘤大小。使用Kaplan-Meier图和单变量和多变量Cox比例风险模型研究IL-6，IL-8和CRP水平，控制变量，总生存期和无病生存期之间的关联。EOC中IL-6，IL-8和CRP的中位血清水平显着高于正常对照组。11.5 pg / mL（范围3.4-62.6）与2.9（1.1-12。3）pg / mL（p <0.001）和21.8 pg / mL（范围16.4-105.3）与9.3（4.3-32.4）pg / mL（p <0.001）和9.51 mg / L（范围0.3-129.2）与分别为1.2（0.1-11.5）mg / L（p = 0.001）。高水平的IL-6，IL-8和CRP与总体生存期降低（P = 0.003，P = 0.035，P = 0.046）和无病生存期（P <0.001，P = 0.026，P = 0.043）有关，分别。多变量分析显示，IL-6，IL-8和CRP血清水平独立预测无病生存期（P = 0.011，P = 0.001和P = 0.021）和总生存期（P = 0.004，P = 0.014和P = 0.016） ）， 分别。EOC与血清细胞因子环境的广泛变化有关，突显了进一步研究相对细胞因子水平变化的重要性。术前血清IL-6，IL-8，CRP水平似乎有望将EOC患者与健康对照区分开来；但是，其临床价值尚待证实。EOC患者中高水平的IL-6，IL-8和CRP被认为是OS和DFS的不良预后因素。