ABSTRACT Active meiotic chromosome movements are a universally conserved feature. They occur at the early stages of prophase of the first meiotic division and support the chromosome pairing process by (1) efficiently installing the synaptonemal complex between homologous chromosomes, (2) discouraging inadvertent chromosome interactions and (3) bringing homologous chromosomes into proximity. Chromosome movements are driven by forces in the cytoplasm, which are passed on to chromosome ends attached to the nuclear periphery by nuclear-membrane-spanning protein modules. In this extra view, we highlight our recent studies into the role of the nuclear lamina during this process to emphasize that it is a highly conserved structure in metazoans. The nuclear lamina forms a rigid proteinaceous network that underlies the inner nuclear membrane to provide stability to the nucleus. Misdemeanors of the nuclear lamina during meiosis has deleterious consequences for the viability and health of the offspring, highlighting the importance of a functional nuclear lamina during this cell cycle stage. Abbreviations: DSB: DNA double strand break; LEM: LAP2, Emerin, MAN1; LINC: LInker of the Nucleoskeleton and Cytoskeleton; RPM: rapid prophase movement; SUN/KASH: Sad1p, UNC-84/Klarsicht, ANC-1, Syne Homology

中文翻译：

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减数分裂染色体运动：核纤层蛋白与它有什么关系？

摘要主动减数分裂染色体运动是一种普遍保守的特征。它们发生在第一次减数分裂前期的早期阶段，并通过 (1) 在同源染色体之间有效地安装联会复合体，(2) 阻止无意的染色体相互作用和 (3) 使同源染色体接近来支持染色体配对过程。染色体运动由细胞质中的力驱动，这些力通过跨核膜蛋白模块传递到附着在核外围的染色体末端。在这个额外的观点中，我们强调了我们最近对核层在此过程中的作用的研究，以强调它是后生动物中高度保守的结构。核层形成一个刚性的蛋白质网络，位于内核膜下方，为细胞核提供稳定性。减数分裂期间核层的不端行为对后代的生存能力和健康产生有害后果，突出了在此细胞周期阶段功能性核层的重要性。缩写：DSB：DNA 双链断裂；LEM：LAP2、Emerin、MAN1；LINC：核骨架和细胞骨架的链接器；RPM：快速前期运动；SUN/KASH：Sad1p、UNC-84/Klarsicht、ANC-1、Syne 同源 人1；LINC：核骨架和细胞骨架的链接器；RPM：快速前期运动；SUN/KASH：Sad1p、UNC-84/Klarsicht、ANC-1、Syne 同源 人1；LINC：核骨架和细胞骨架的链接器；RPM：快速前期运动；SUN/KASH：Sad1p、UNC-84/Klarsicht、ANC-1、Syne 同源