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Recent Development on Anti-Obesity Compounds and their Mechanisms of Action: A Review.
Current Medicinal Chemistry ( IF 4.1 ) Pub Date : 2020-05-31 , DOI: 10.2174/0929867326666190215114359
Yixing Qiu 1, 2 , Huanghe Yu 1 , Rong Zeng 1 , Shiyin Guo 3 , Muhammad Daniyal 1 , Zeyu Deng 1 , Aibing Wang 2 , Wei Wang 1
Affiliation  

Obesity, associated with a series of complications such as diabetes, hypertension, and heart disease, is a great threat to human health and leads to increased morbidity and mortality. Despite the presence of anti-obesity agents on the market, the application of these drugs is limited because of their typical side effects. More effective and safe weight-loss drugs are being pursued by many researchers, correspondingly, growing small molecules and natural products with anti-obesity effects have been identified and the molecular mechanisms underlying the action of the novel and known compounds have at least partially been revealed. Therefore, the field does witness great progress year by year. In this review, we intend to provide a comprehensive and updated view on the known and novel compounds which possess anti-obesity effects and further classify them according to the molecular mechanisms of their actions in regulating the major anti-obesity pathways.



中文翻译:

反肥胖化合物及其作用机理的最新进展:综述。

肥胖与糖尿病,高血压和心脏病等一系列并发症相关,对人类健康构成巨大威胁,并导致发病率和死亡率增加。尽管市场上存在抗肥胖剂,但是由于它们的典型副作用,这些药物的应用受到限制。许多研究人员正在寻求更有效和安全的减肥药,相应地,已经鉴定出具有抗肥胖作用的小分子和天然产物的生长,并且至少部分揭示了新颖和已知化合物作用的分子机制。 。因此,该领域每年都在取得长足进步。在这篇评论中

更新日期:2020-05-31
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