Placental oxygenation varies throughout pregnancy. The detection of early changes in placental oxygenation as pregnancy progresses is important for early identification of preeclampsia or other complications. This invited commentary discusses a recent preclinical study on the application of 3-dimensional photoacoustic imaging (PAI) for assessment of regional variations in placental oxygenation and longitudinal analysis of differences in placental oxygenation throughout normal pregnancy and pregnancy associated with hypertension or placental insufficiency in mice. Three-dimensional PAI more accurately reflects oxygen saturation, hemoglobin concentrations, and changes in oxygen saturation in whole placenta compared to 2-dimensional imaging. These studies suggest that PAI is a sensitive tool to detect different levels of oxygen saturation in the placental and fetal vasculature in pathologic and normal pregnancy in mice.

中文翻译：

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正常和病理妊娠中胎盘的临床前超声引导下的光声成像。

胎盘氧合在整个怀孕期间有所不同。随着怀孕的进行，胎盘氧合的早期变化的检测对于早期识别先兆子痫或其他并发症很重要。这篇受邀的评论讨论了有关3D光声成像（PAI）用于评估胎盘氧合的区域变化以及纵向分析整个正常妊娠以及与小鼠高血压或胎盘供血不足有关的妊娠中胎盘氧合差异的纵向分析的近期临床前研究。与二维成像相比，三维PAI更准确地反映了整个胎盘中的氧饱和度，血红蛋白浓度和氧饱和度的变化。