当前位置: X-MOL 学术AIDS Rev. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Non-Alcoholic Fatty Liver Disease in Patients with HIV Infection
AIDS Reviews ( IF 2.2 ) Pub Date : 2018-9-29 , DOI: 10.24875/aidsrev.18000008
Marianthi Papagianni 1 , Konstantinos Tziomalos 2
Affiliation  

Non-alcoholic fatty liver disease (NAFLD) is highly prevalent in patients with HIV infection and appears to be more severe than in HIV-uninfected patients. Both metabolic (e.g., obesity and insulin resistance) and HIV-related factors (e.g., antiretroviral treatment and inflammation) play a role in the pathogenesis of NAFLD in this population. Accordingly, all patients with HIV infection should be evaluated for the presence of NAFLD. Ultrasound is the first-line diagnostic procedure, but non-alcoholic steatohepatitis has to be diagnosed with liver biopsy. However, non-invasive methods, including serological markers and transient elastography, might also be useful in this population. Lifestyle changes represent the cornerstone of treatment. Bariatric surgery, pioglitazone, and vitamin E can be considered in patients with significant fibrosis or at high risk for progression of NAFLD, including those with type 2 diabetes mellitus, metabolic syndrome, elevated transaminases, or pronounced necroinflammation. However, there are no studies that evaluated the safety of efficacy of diet, exercise, or pharmacotherapy in this population. Therefore, research is needed to identify safe and effective pharmacological treatments for NAFLD in patients with HIV infection.

中文翻译:

HIV感染患者的非酒精性脂肪肝疾病

非酒精性脂肪肝疾病(NAFLD)在感染HIV的患者中非常普遍,并且比未感染HIV的患者更为严重。代谢(例如,肥胖和胰岛素抵抗)和HIV相关因素(例如,抗逆转录病毒治疗和炎症)都在该人群NAFLD的发病机理中起作用。因此,应评估所有感染HIV的患者是否存在NAFLD。超声是一线诊断程序,但非酒精性脂肪性肝炎必须通过肝活检诊断。但是,包括血清学标志物和瞬时弹性成像在内的非侵入性方法在该人群中也可能有用。生活方式的改变是治疗的基石。减肥手术,吡格列酮,纤维化严重或NAFLD进展风险高的患者可以考虑使用维生素E和维生素E,包括患有2型糖尿病,代谢综合征,转氨酶升高或明显坏死性炎症的患者。但是,尚无研究评估该人群饮食,运动或药物疗法的疗效安全性。因此,需要进行研究以鉴定HIV感染患者中NAFLD的安全有效药物治疗。
更新日期:2020-08-21
down
wechat
bug