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Treatment as Prevention for HIV Infection: Current Data, Challenges, and Global Perspectives
AIDS Reviews ( IF 2.2 ) Pub Date : 2018-9-29 , DOI: 10.24875/aidsrev.m18000024
Jean C Yombi 1 , Helena Mertes 2
Affiliation  

In 2008, the Swiss National AIDS Commission issued a statement about the safety of HIV treatment in terms of reduced transmission in serodiscordant couples to reduce transmission in serodiscordant couples. This was subjected to debate until 2011 when the HIV prevention trial network 052 published the first randomized study about HIV transmission in serodiscordant couples, where no transmission was observed when the infected person was under effective antiretroviral treatment (ART). Later, the Partners of People on ART-A New Evaluation of the Risks (PARTNER) and the opposites attract studies, which first involved a large number of men who have sex with men (MSM), also showed no transmission, even in condomless receptive anal intercourse (CLAI). In this article, we first review the major studies' data showing the efficacy of ART in HIV transmission in serodiscordant couples at public health scale. Second, we discuss the implications and challenges behind the treatment as prevention strategy regarding the 90-90-90 UNAIDS targets to end the HIV epidemic.We now have strong evidence that ART reduces the risk of transmission of HIV from a positive partner to their negative partner. However, far beyond ART, combining prevention policies is crucial to avoid a new increase in the overall HIV incidence.

中文翻译:

作为预防艾滋病毒感染的治疗方法:当前数据,挑战和全球视角

2008年,瑞士国家艾滋病委员会发表了一份声明,关于艾滋病毒治疗的安全性,即减少血清胶粘剂夫妇的传播,以减少血清胶粘剂夫妇的传播。直到2011年HIV预防试验网络052公布了关于血清抗粘液性夫妇中HIV传播的第一项随机研究时,这才引起争议,当感染者接受有效的抗逆转录病毒治疗(ART)时,没有观察到传播。后来,ART-A风险伙伴的新评估(PARTNER)及其对立面吸引了许多研究,这些研究首先涉及大量与男性发生性关系的男性(MSM),即使没有避孕套,也没有传播肛交(CLAI)。在本文中,我们首先回顾主要研究 数据显示了在公共卫生规模上抗逆转录病毒疗法夫妇中HIV传播ART的功效。其次,我们讨论了针对90-90-90联合国艾滋病规划署(UNAIDS)结束艾滋病毒流行目标的预防策略作为治疗策略的意义和挑战。伙伴。但是,远远超过抗逆转录病毒疗法,综合预防政策对于避免总体艾滋病毒感染率再次增加至关重要。
更新日期:2020-08-21
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