ABSTRACT Moderate intensity low frequency rotating magnetic field (LF-RMF) has been shown to inhibit melanoma, liver and lung cancer growth in mice. However, its effects on other types of cancers have not been investigated in vivo. Here, we show that 0–0.15T moderate intensity 4.2 Hz LF-RMF can inhibit tumor growth in mice bearing MDA-MB231 and MCF7 human breast cancer cells by over 30%. In contrast, the human gastrointestinal stromal tumor GIST-T1 growth was not inhibited by LF-RMF. In all RMF treatments, there were no apparent adverse effects on mice organs, body weight or water/food consumptions. However, the alanine aminotransferase (ALT) level was decreased in LF-RMF-treated mice bearing MCF7 and GIST-T1 cells, which indicated alleviated liver damage. Therefore, our study shows that moderate intensity LF-RMF might be a safe physical method that has clinical potentials to be used to inhibit breast cancer growth in the future.

中文翻译：

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中等强度低频旋转磁场抑制小鼠乳腺癌生长

摘要 中等强度低频旋转磁场 (LF-RMF) 已被证明可以抑制小鼠黑色素瘤、肝癌和肺癌的生长。然而，尚未在体内研究其对其他类型癌症的影响。在这里，我们表明 0-0.15T 中等强度 4.2 Hz LF-RMF 可以抑制携带 MDA-MB231 和 MCF7 人乳腺癌细胞的小鼠的肿瘤生长超过 30%。相比之下，人胃肠道间质瘤 GIST-T1 的生长不受 LF-RMF 的抑制。在所有 RMF 治疗中，对小鼠器官、体重或水/食物消耗没有明显的不利影响。然而，LF-RMF 处理的携带 MCF7 和 GIST-T1 细胞的小鼠的丙氨酸转氨酶 (ALT) 水平降低，这表明肝损伤减轻。所以，