Flubendiamide is widely used in agricultural fields to exterminate a broad spectrum of pests (lepidopteran insects) by disrupting their muscle function. The main objective of this study was to find the effects of flubendiamide on a non-target organism, Drosophila melanogaster (dipteran insect). In the present study, different sub-lethal concentrations of Flubendiamide caused a significant (P < 0.05) decrease in acetylcholinesterase activity and increase in cytochrome P450 activity in adult D. melanogaster. Phototaxis and climbing behaviours were found to significantly (P < 0.05) alter in exposed flies. The observed alteration in phototaxis and climbing behaviours were not restricted to P generation, but were found to be transmitted to subsequent generations (F₁ and F₂ generation) that had never been directly exposed to the test chemical during their life time. It is only their predecessors (P generation) who have been affronted with different concentrations of Flubendiamide. Humans and Drosophilids share almost 60% genomic similarity and 75% disease gene resemblance. Moreover, most of the circuits governing the behaviours studied involve the inhibition and excitation of neurotransmitters, which are conserved in humans and flies. Thus, the present findings suggest that chronic flubendiamide exposure might induce alteration in neurotransmission leading to discrepancy in the behavioural responses (vision and flight) in other beneficial insects and insect-dependent organisms.

中文翻译：

---

氟苯二酰胺连续三个世代（P，F1和F2）影响果蝇的视觉和运动功能。

氟苯二酰胺广泛用于农业领域，可通过破坏其肌肉功能来消灭各种害虫（鳞翅目昆虫）。这项研究的主要目的是发现氟苯二酰胺对非靶标生物果蝇（Drosophila melanogaster）（双翅类昆虫）的影响。在本研究中， 成年D. melanogaster的不同亚致死浓度的氟苯甲酰胺导致乙酰胆碱酯酶活性显着降低（P <0.05），细胞色素P450活性升高。发现趋光性和攀爬行为显着（P <0.05）暴露的果蝇发生变化。观察到的趋光性和爬升行为的变化不仅限于P世代，而且还被发现传播至其生命中从未直接暴露于测试化学品的后世代（F ₁和F ₂世代）。只是他们的前辈（P代）曾遭受不同浓度的氟苯二酰胺的侵害。人类和果蝇共有近60％的基因组相似性和75％的疾病基因相似性。而且，支配所研究行为的大多数回路都涉及神经递质的抑制和激发，而神经递质在人和果蝇中均是保守的。因此，本研究结果表明，长期服用氟苯二酰胺可能会引起神经传递的改变，从而导致其他有益昆虫和昆虫依赖性生物的行为反应（视觉和飞行）出现差异。