Due to change in lifestyle and food habits, people are more at risk of diet-related diseases and cancers. It is also established that dietary modifications significantly reduce the risk of diseases. Nutrigenomics is relatively fresh discipline, but possess an enormous potential that can apply for prevention and management of certain carcinomas and diseases. This review enables us to generate useful information for scientists and health professionals regarding the role of Nutrigenomics in the prevention of diet and lifestyle-related diseases like cancer. It influences health conditions of individuals and susceptibility of disease by defining the metabolic response and gene expression. Epigenetic modifications can perform a significant role in disease occurrence and pathogenesis. DNA methylation and chromatin remodeling are the most common epigenetic mechanisms. Omega 3 fatty acids are the best example of nutrients and gene interaction not involving DNA methylation while certain bioactive food compounds have a proven role in cancer prevention through an epigenetic mechanism. Dietary polyphenols substantially take part in prevention of oral, breast, skin, esophageal, colorectal, prostate, pancreatic and lung cancers. Moreover, minerals and vitamins involve regulatory processes. Zinc, Selenium and folate involve in DNA repairing process have anticancer properties. Consumption of multivitamins prevents methylation of cancer cells.

中文翻译：

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营养基因组学：表观遗传学和癌症预防：全面综述。

由于生活方式和饮食习惯的改变，人们更容易患上与饮食相关的疾病和癌症。还已经确定饮食结构的改变显着降低了疾病的风险。营养基因组学是一门相对较新的学科，但具有巨大的潜力，可用于某些癌症和疾病的预防和管理。这项综述使我们能够为科学家和卫生专业人员提供有关营养基因组学在预防饮食和与生活方式有关的疾病（如癌症）中的作用的有用信息。它通过定义代谢反应和基因表达来影响个体的健康状况和疾病的易感性。表观遗传修饰可以在疾病发生和发病机理中发挥重要作用。DNA甲基化和染色质重塑是最常见的表观遗传机制。欧米茄3脂肪酸是不涉及DNA甲基化的营养物质和基因相互作用的最佳实例，而某些生物活性食品化合物通过表观遗传机制在癌症预防中具有公认的作用。饮食中的多酚主要参与预防口腔癌，乳腺癌，皮肤癌，食道癌，结直肠癌，前列腺癌，胰腺癌和肺癌。此外，矿物质和维生素涉及调节过程。锌，硒和叶酸参与DNA修复过程具有抗癌作用。食用多种维生素可防止癌细胞甲基化。欧米茄3脂肪酸是不涉及DNA甲基化的营养物质和基因相互作用的最佳实例，而某些生物活性食品化合物通过表观遗传机制在癌症预防中具有公认的作用。饮食中的多酚主要参与预防口腔癌，乳腺癌，皮肤癌，食道癌，结直肠癌，前列腺癌，胰腺癌和肺癌。此外，矿物质和维生素涉及调节过程。锌，硒和叶酸参与DNA修复过程具有抗癌作用。食用多种维生素可防止癌细胞甲基化。欧米茄3脂肪酸是不涉及DNA甲基化的营养物质和基因相互作用的最佳实例，而某些生物活性食品化合物通过表观遗传机制在癌症预防中具有公认的作用。饮食中的多酚主要参与预防口腔癌，乳腺癌，皮肤癌，食道癌，结直肠癌，前列腺癌，胰腺癌和肺癌。此外，矿物质和维生素涉及调节过程。锌，硒和叶酸参与DNA修复过程具有抗癌作用。食用多种维生素可防止癌细胞甲基化。硒和叶酸参与DNA修复过程具有抗癌作用。食用多种维生素可防止癌细胞甲基化。硒和叶酸参与DNA修复过程具有抗癌作用。食用多种维生素可防止癌细胞甲基化。