Gastrointestinal tract is the second largest organ in the body that mainly functions in nutrients and minerals intake through the intestinal barrier. Intestinal permeability maintains the circulation of minerals and nutrients from digested foods. Life and all the metabolic processes depend either directly or indirectly on proper functioning of GI tract. Compromised intestinal permeability and related disorders are common among all the patients with inflammatory bowel disease (IBD), which is a collective term of inflammatory diseases including Crohn's disease and ulcerative colitis. Many synthetic drugs are currently in use to treat IBD such as 5-aminosalicylic acid corticosteroids. However, they all have some drawbacks as long-term use result in many complications. These problems encourage us to look out for alternative medicine. Numerous in vitro and in vivo experiments showed that the plant-derived secondary metabolites including phenolic compounds, glucosinolates, alkaloids, terpenoids, oligosaccharides, and quinones could reduce permeability, ameliorate-related dysfunctions with promising results. In addition, many of them could modulate enzymatic activity, suppress the inflammatory transcriptional factors, ease oxidative stress, and reduce pro-inflammatory cytokines secretion. In this review, we summarized the phytochemicals, which were proven potent in treating increased intestinal permeability and related complication along with their mechanism of action.

中文翻译：

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植物化学物质和炎性肠病：综述。

胃肠道是人体内第二大器官，主要通过肠屏障吸收营养和矿物质。肠渗透性维持消化食品中矿物质和营养物质的循环。生命和所有新陈代谢过程直接或间接取决于胃肠道的正常功能。肠道通透性受损和相关疾病在所有炎症性肠病（IBD）患者中都很常见，IBD是包括克罗恩氏病和溃疡性结肠炎在内的炎症性疾病的统称。当前，许多合成药物用于治疗IBD，例如5-氨基水杨酸皮质类固醇。然而，它们都具有一些缺点，因为长期使用会导致许多并发症。这些问题促使我们寻找替代药物。大量的体外和体内实验表明，植物衍生的次级代谢产物，包括酚类化合物，芥子油苷，生物碱，萜类化合物，低聚糖和醌类，可以降低通透性，改善相关功能障碍，具有可喜的结果。此外，它们中的许多可以调节酶活性，抑制炎性转录因子，减轻氧化应激并减少促炎性细胞因子的分泌。在这篇综述中，我们总结了植物化学物质，它们被证明可有效治疗肠道通透性增加和相关并发症以及它们的作用机理。改善与功能有关的功能障碍，取得可喜的结果。此外，它们中的许多可以调节酶活性，抑制炎性转录因子，减轻氧化应激并减少促炎性细胞因子的分泌。在这篇综述中，我们总结了植物化学物质，它们被证明可有效治疗肠道通透性增加和相关并发症以及它们的作用机理。改善与功能有关的功能障碍，取得可喜的结果。另外，它们中的许多可以调节酶活性，抑制炎性转录因子，减轻氧化应激和减少促炎性细胞因子的分泌。在这篇综述中，我们总结了植物化学物质，它们被证明可有效治疗肠道通透性增加和相关并发症以及它们的作用机理。